Women are advised against taking alpha blockers during pregnancy, especially during the second and third trimesters. Patients taking alpha blockers should inform their physician immediately if they become pregnant or are planning to become pregnant, so that they can start alternative therapy.

When breast feeding, some alpha blockers will pass into breast milk. While this has not been found to cause problems in nursing infants, an alternative feeding method may be recommended when alpha blockers are being used by the mother. Parents should weigh the benefits and risks with their physicians.