Certain medical conditions may affect the use of individual analgesics and analgesic combinations. Patients should inform their physician of any of the following:

• Anemia
• Asthma, allergies or history of nasal polyps
• Brain disease or head injury
• Colitis
• Emotional problems or mental illness
• Emphysema or other chronic lung disease
• Enlarged prostate or problems with urination (dysuria)
• Gallbladder disease or gallstones
• Gout
• Heart disease
• Hemophilia or other bleeding problems
• History of alcohol or other drug abuse
• History of convulsions (seizures)
• Kidney disease
• Liver disease
• Overactive or underactive thyroid gland (hyperthyroidism or hypothyroidism)
• Stomach ulcer or other stomach problems
• Vitamin K deficiency