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Certain conditions increase the risk of side effects or other potential problems for patients taking angiotensin-II receptor blockers (ARBs). These include:
- Previous allergic reaction to ARBs or similar medications (e.g., ACE inhibitors).
- Valvular stenosis (particularly in the aortic or mitral valves). A condition in which there is a narrowing, stiffening, thickening or blockage of one or more heart valves.
- Angioedema. A type of edema (swelling) in the head, neck, face, ankles or legs that can lead to difficulty breathing or swallowing.
- Kidney or liver disease. Blood pressure-lowering effects of ARBs may be increased in patients with these conditions.
- Pregnancy. ARB use may cause birth defects.
- Dehydration. Blood pressure-lowering effects of ARBs may be increased in dehydrated patients.
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