Women are advised against taking Angiotensin–II receptor blockers (ARBs) during pregnancy, especially during the second and third trimesters. Patients taking ARBs should inform their physician immediately if they become pregnant or are planning to become pregnant, so they can start alternative therapy.

When breastfeeding, some ARBs will pass into breast milk, and the effects of this on the nursing infant are unknown. Therefore, an alternative feeding method is recommended when mothers are taking ARBs.