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Patients who overdose on the anti-anxiety drug buspirone are likely to experience severe dizziness, drowsiness, abnormal constriction of pupils and stomach upset that may include nausea and vomiting.

Overdoses of antihistamines may produce sedation, reduced mental alertness, apnea (temporary absence of breathing), cardiovascular collapse, hallucinations, seizures and dry mouth. Overdoses of beta blockers may trigger severe hypotension (abnormally low blood pressure), bradycardia (slowness of heart rate), heart failure or bronchospasm.

Overdoses of clonidine may cause bradycardia, central nervous system depression and respiratory depression. Overdoses of tiagabine may result in drowsiness, impaired consciousness or speech, or agitation and confusion.

Very rarely, benzodiazepine  overdoses may cause hypotension (low blood pressure).