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Studies do not agree on the safety of antidepressants during pregnancy or breastfeeding. Most antidepressants do not seem to be associated with an increased risk of birth defects or miscarriage. However, it is important to note that the selective serotonin reuptake inhibitor (SSRI) paroxetine appears to be more likely to be associated with birth defects, and that some antidepressants may be associated with reduced birth weight.

Most antidepressants also seem to be safe during breastfeeding. Though the medications are excreted in breast milk, they do not appear to cause any harm to the infant. Regardless, the benefits and potential risks of antidepressants must be weighed for each patient. Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants may be associated with greater risks than selective serotonin reuptake inhibitors. Any woman taking antidepressants who is nursing, pregnant or plans to become pregnant should discuss the medication with an obstetrician.