Antidiabetic agents may cause additional risk for individuals who now or used to have certain health problems. Patients should inform their physician of these health conditions before undergoing treatment. Antidiabetic agents should not be used to treat diabetic ketoacidosis, according to the U.S. Food and Drug Administration. Additional conditions of concern may include:

• Other endocrine disorders, such as thyroid, pituitary or adrenal disease
• Kidney disorders

• Liver disease
• Heart conditions, including coronary artery disease and heart failure
• Pregnancy
• Severe injury, burn or infection
• Major surgery
• Osteoporosis

Conditions of concern vary according to the individual drug. Patients are advised to ask their physician about their particular medication and class of medications.