When first taking antihypertensives, patients are advised to avoid driving or operating other heavy machinery until they know how the medication will affect them. Most people on medication to treat high blood pressure will be taking it for the rest of their lives, provided no serious side effects occur.

Patients should remember that antihypertensives control high blood pressure but do not cure it. They should also know that over time, some antihypertensive medication may become less effective in treating their condition, and they may have to switch to another dosage or drug.

Patients are encouraged to continue to see their physician for regular follow-up to ensure that their blood pressure is under control, even if it appears that symptoms have been relieved. Controlling glucose (blood sugar) can also help people with diabetes lower their blood pressure. In addition to taking their medications as prescribed, patients may be advised to make lifestyle modifications, especially concerning a nutritious diet, exercise, weight loss, quitting smoking and stress management.

Patients should inform their physician if they become sick, especially with severe vomiting or diarrhea. These conditions could cause the body to lose too much water and potassium, leading to dehydration and low blood pressure (hypotension).

A person's exposure to heat may intensify the adverse effects of antihypertensives. Patients should drink enough liquids during exercise or in hot weather and adhere to their physician’s instructions regarding exercise, activity levels and diet.