Patients should consult their physician before taking any additional prescriptions, over-the-counter medications, nutritional supplements or herbal medications. Of particular concern to individuals taking anticholinergics are:

• Other anticholinergics. Taking multiple types of anticholinergics can interfere with the effects of one or both.
  
  
• Antacids. Used to neutralize acid in the stomach. They may interfere with the normal effects of anticholinergics.
  
  
• Kaolin or attapulgite. Used to treat diarrhea. These can impair the effectiveness of anticholinergics.
  
  
• Ketoconazole. Used to treat fungal infections. It can lessen the usual effects of anticholinergics.
  
  
• Central nervous system (CNS) depressants. Used to slow normal brain function. Taking these drugs with anticholinergics can increase the effects of either medicine.
  
  
• Tricyclic antidepressants. Used to treat anxiety disorders and attacks. These medications can increase the effects of anticholinergics.
  
  
• Potassium chloride. Mineral necessary for the proper operation of many body functions, particularly heart function. Taking potassium supplements with anticholinergics can worsen the gastrointestinal side effects that may occur with potassium use.
  
  
• Alcohol. Taken either as a recreational drink or in some medications (e.g., cough syrups). Mixing alcohol with anticholinergics can result in confusion, dizziness and disorientation.