Most physicians recommend that pregnant women avoid the use of anticholinergics during pregnancy. Anticholinergics can cause the heartbeat of an unborn child to increase when the pregnant mother uses this type of medication. Pregnant women and women who wish to become pregnant should discuss the use of anticholinergics with their physicians before using this type of medication.

While it has not been confirmed through clinical studies, the anticholinergic dicyclomine (used to treat bowel syndrome) has been associated with some birth defects when taken by pregnant women.

Physicians do not believe that anticholinergics pass into breast milk, but this medication may reduce the flow of milk in breastfeeding mothers. Nursing mothers are encouraged to drink more fluids and contact their physician if this occurs. There have been some reports that the anticholinergic dicyclomine causes breathing problems in infants when used by nursing mothers. Breastfeeding mothers should consult their physician before using anticholinergics.