Several side effects associated with antispasmodics may require patients to make adjustments to their lifestyle routines. For example, drowsiness is commonly associated with these drugs, so patients should be careful not to drive, use machines or engage in any potentially dangerous activities if they feel drowsy or dizzy. The risk of dizziness and associated fainting may be reduced by rising slowly from lying or sitting positions.

Dryness of the mouth can be relieved by eating sugarless candy or chewing sugarless gum, sucking on ice, or using a synthetic saliva substitute available at pharmacies. However, continued dryness of the mouth can increase the risk of dental problems and may require a visit to a physician.

Patients who take antispasmodics may also sweat less, causing their body temperature to rise. As a result, patients should exercise caution so they do not overheat during hot weather or while exercising. Hot baths and saunas should also be avoided.