However, drug companies say the review is flawed. GlaxoSmithKline, the maker of Paxil, stated: "Contrary to what has been reported, this study has only examined a small subset of the total data available for antidepressants. With paroxetine for example, this study only considers data from 16 trials out of a total database of more than 170 trials involving at least 14,000 patients."

The American Psychiatric Association (APA) said the study showed the importance of individualizing treatment. "Medication helps some, but not all people with depression. For people with mild to moderate depression, psychotherapy can work as well as medication," said Dr. Nada Stotland, APA president-elect.

What Patients Should Know

Concerned patients should consult their doctors, especially when it relates to stopping antidepressants. "Never discontinue medication without talking to the doctor about it," the National Institutes of Mental Health (NIMH) stresses. "Although antidepressants are not habit-forming or addictive, abruptly ending an antidepressant can cause withdrawal symptoms or lead to a relapse."

Individuals vary widely in how they respond to antidepressants. The drugs take time to reach their full effects -even up to six weeks. And some people go through three or four different drugs before they find one that works for them. The drugs can be a lifesaver for some but might not the best choice for others.