People may avert some arthritic conditions by avoiding infections - for example, using tick repellent to prevent Lyme disease and practicing safe sex to prevent the sexually transmitted diseases that can cause Reiter's syndrome.

However, there is no sure way to prevent most forms of arthritis. Yet many of the lifestyle changes used to treat arthritis may help prevent it or delay its onset. Avoiding trauma and injury, through means such as using seatbelts and wearing protective sports equipment, may help keep from predisposing the joint to early osteoarthritis (OA). Avoiding obesity or losing weight if necessary reduces stress and weight on the body's joints. Healthy levels of exercise (approved by a physician) can help maintain muscle strength and minimize the likelihood of joint injury.

Another preventive measure is to quit smoking or never start. In addition to the many other health hazards caused by tobacco use, researchers have found that some smokers have an increase risk of rheumatoid arthritis and might be at risk for a worsening of OA.

A healthful diet rich in produce may also help. Recent studies suggest that carotenoids (found in orange and yellow vegetables and fruits) and certain enzymes in cruciferous vegetables (the broccoli and cabbage family) could protect the joints and help stave off arthritis. Some research indicates the mineral selenium, found in many foods, may help prevent OA.

Good posture and ergonomics can prevent exacerbations of arthritis and help people function in the workplace and in other daily tasks.