Arrhythmogenic right ventricular dysplasia (ARVD) is a genetic disease in which the muscle tissue in the lower-right chamber of the heart (right ventricle) degenerates and is replaced by fat. As a result, patients can develop dangerous abnormal heart rhythms (arrhythmias) or even go into cardiac arrest, particularly when under physical or emotional stress. Studies have shown that ARVD is a significant cause of sudden cardiac death among young athletes.

In some cases, symptoms appear in childhood and can quickly worsen. In most cases, however, symptoms do not appear until patients are in their 30s or 40s. By that time, ARVD may have progressed to heart failure.

There is no known cause or cure of ARVD, although there is a clear genetic link. Patients with ARVD have a 50 percent chance of passing the condition along to their children. Researchers are currently working to develop gene therapy to treat ARVD. In the meantime, treatment for ARVD is aimed at controlling the arrhythmias that could lead to a life-threatening cardiac event.

Support is available for ARVD patients and their families. Patients are encouraged to contact the ARVD Registry of North America for further information about the disease and about contacting others with the same condition. By registering as someone with ARVD, patients can also help researchers develop better treatments and diagnostic tools. The registry can be reached by calling 800-483-2662.