Some of the conditions and symptoms associated with aspirin sensitivity include:

• Asthma. Usually appears as part of Samter’s triad, which includes three elements: aspirin sensitivity, nasal polyps (sac-like growths in the nose) and asthma. About 10 percent of adults with asthma (and 40 percent with nasal polyps) have symptoms triggered by taking these drugs, according to the American Academy of Allergy, Asthma and Immunology. These asthma attacks are often severe, and in some cases can be life-threatening.

  

• Severe allergic-type reactions. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase, which keeps prostaglandins from triggering pain and inflammation. However, in aspirin-sensitive individuals, production of leukotrienes increases. Leukotrienes are powerful bronchodilators and vasodilators that can trigger symptoms similar to those of an allergic reaction. Symptoms that typically appear include nasal discharge (rhinorrhea), nasal polyps and – very rarely – anaphylactic shock, which is a life-threatening allergic reaction.

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• Urticaria and angioedema. According to the American Academy of Allergy, Asthma and Immunology (AAAAI), 20 to 80 percent of people with chronic (ongoing) urticaria (hives) and angioedema (swelling) will experience a worsening of the conditions after taking the drugs. This can result in swelling of the airway. Individuals with urticaria and angioedema should consult a physician before using aspirin.
  
  
• Reye syndrome. A rare condition that causes swelling of the brain and fatty deposits in the liver of children who take aspirin to treat fever brought on by chicken pox, flu and other viral infections. Symptoms include vomiting, confusion, loss of consciousness and high blood pressure. Severe cases can cause brain damage or death. Parents and other caregivers should avoid giving aspirin or other NSAIDs to a child unless advised to do so by a physician.
  
  
• Gastrointestinal problems. NSAIDs help relieve pain and inflammation by suppressing chemicals in the body called prostaglandins. However, prostaglandins also protect the stomach lining, because they suppress the risk of gastric acid eroding the stomach lining and causing bleeding and ulcers.
  
  
• Bruising and bleeding. NSAIDs have anticoagulant effects, causing some people to bruise or bleed more easily. In addition, use of aspirin during pregnancy may affect the clotting mechanisms of both the mother and the fetus, leading to an increased risk of bleeding. This is especially true if high doses of aspirin are taken.

Other general symptoms of sensitivity to NSAIDs include:

• Ringing in the ears
• Headache
• Runny nose
• Itchy, watery, swollen eyes
• Dizziness
• Cough
• Drowsiness
• Breathing difficulties
• Wheezing
• Mouth sores
• Skin rashes

Individuals who suspect sensitivity to aspirin or other NSAIDs should avoid the drug and consult a physician.