High pressure blood (hypertension). The exact mechanism of how beta blockers lower blood pressure is unknown. There are a variety of effective antihypertensive medications available and physicians consider a number of factors when recommending a medication. In general, beta blockers are not considered first-line therapy for high blood pressure, but may be added to an antihypertensive regimeHypertension is the medical term for high blood pressure (the force of blood against artery walls).n, either as a stand-alone drug or in combination with other blood pressure lowering drugs. Some studies have also examined beta blockers among different age or racial groups. In general, younger patients were shown to respond better to beta blockers than older patients.