There are a number of side effects associated with bile acid resins. The most common of these is constipation, for which physicians will often prescribe a stool softener or laxative. Patients may be instructed to take stool softeners for a day or two before they begin taking bile acid resins. Patients may also experience stomach irritation or diarrhea upon starting bile acid resins.These symptoms often disappear after a few weeks, when the body has become more accustomed to the medication.

Patients should notify their physician immediately if they experience an allergic reaction, which can include sneezing, congestion, itching or skin rashes. In addition, specific drugs have been associated with the following side effects: