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Biological Therapy Drugs

Also called: Biological Agents, Biological Response Modifiers, Biological Drugs, BRMs

- Summary
- About biological therapy drugs
- Types and differences
- Potential side effects
- Pregnancy use issues
- Questions for your doctor

Reviewed By:
Martin E. Liebling, M.D., FACP

Potential side effects of biological therapy

While biological therapy drugs have shown great benefits in treating some cancers, they may also cause side effects. These may include:

  • Rashes or swelling at an injection site

  • Flu–like symptoms, including fever, chills, nausea, vomiting, diarrhea, loss of appetite, fatigue, bone pain and muscle aches

  • Low blood pressure

  • Allergic reactions

Patients who experience any of these side effects should consult a physician.

The types and frequency of side effects associated with biological therapy drugs varies between drug classes and can include:

  • Interferons:
    • Decreased appetite
    • Seizures
    • Changes in taste, and dry mouth or throat
    • Partial hair loss
    • Impotence
    • Menstrual irregularities

  • Interleukins:
    • Decreased red blood cell count (anemia)
    • Decreased urine output
    • Mouth or lip sores
    • Impaired memory
    • Difficulty talking
    • Fluid in the lungs
    • Peeling of skin on hands and feet

  • Monoclonal antibodies:
    • Swelling of the tongue or throat
    • Generalized pain
    • Abdominal or bone pain
    • Cough with shortness of breath

  • Colony-stimulating factors:
    • Swelling of feet
    • Weight gain
    • Bone pain

Patients who are receiving biological therapy and experience these symptoms should promptly advise their physicians.

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Review Date: 08-13-2008
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