• Heart failure. A serious chronic condition in which the heart does not pump enough to meet the body’s need for oxygen. Shortness of breath is one of the earliest symptoms of heart failure.

  • Valvular heart disease (e.g., valvular stenosis or valvular regurgitation). This condition may occur in any of the four valves of the heart: the aortic valve, the mitral valve, the tricuspid valve or the pulmonary valve. Normally, these valves allow blood to flow in only one direction and only at the right time during a heartbeat. Valvular heart disease can lead to blood flow being restricted due to a narrowed valve (stenosis), or blood flow leaking in the wrong direction (regurgitation). Shortness of breath can occur as a result of the restricted or misdirected blood flow.