Use during pregnancy must be evaluated on a case-by-case basis. These drugs will be prescribed if the physician decides that the benefits outweigh the risks. Although the effects of calcium channel blockers during pregnancy have not been studied in humans, animal studies have shown that large doses of certain calcium channel blockers can produce prolonged pregnancy, birth defects, poor bone development in the newborn and stillbirth. Other calcium channel blockers have shown no harm in animal studies.

When breast feeding, some calcium channel blockers will pass into breast milk, but this has not been found to cause problems in nursing infants.