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The risk factors for carotid artery disease are similar to those for coronary artery disease - atherosclerosis of the main arteries carrying oxygen-rich blood to the heart (the coronary arteries). Therefore, people with one condition often have other cardiovascular problems. risk factors for both (as shown by a coronary risk profile) that can be modified include the following:
- Smoking
- Lack of regular exercise
- Eating a diet high in saturated fats
- Obesity
- Uncontrolled diabetes and high blood pressure (hypertension)
- Uncontrolled stress and anger
- High LDL (“bad”) cholesterol levels and low HDL (“good”) cholesterol levels.
- Currently undergoing hormone replacement therapy (HRT)
Risk factors that cannot be modified include the following:
- Gender. Men and women face different risks. For example, women are more likely to both have a stroke and die from a stroke, according to the American Heart Association (AHA).
- Advanced age. Cardiovascular diseases, as well as peripheral arterial disease, tend to affect older people more than younger people.

- Ethnicity. Members of certain groups, such as black Americans, have a higher statistical risk for high blood pressure, which, in turn, is a risk factor for both stroke and heart attack
- A family history of carotid artery disease or coronary artery disease.
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