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Clot Busting Drugs

Also called: APSAC, Tissue Plasminogen Activator, rt-PA, Thrombolytic Enzymes, Thrombolytic Drugs, Thrombolytic Agents, t-PA

- Summary
- About clot-busting drugs
- Conditions treated
- Conditions of concern
- Potential side effects
- Drug or other interactions
- Symptoms of overdose
- Pregnancy use issues
- Child use issues
- Elderly use issues
- Questions for your doctor

Reviewed By:
Kerry Prewitt, M.D., FACC
Abdou Elhendy, MD, PhD, FACC, FAHA
Robert I. Hamby, M.D., FACC, FACP

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Drug or other interactions with clot-busters

Patients should consult their physician before taking any other medication (either prescription or over-the-counter), herbal remedies or nutritional supplements. Of particular danger to individuals taking clot busters are some forms of:

Anticoagulants
Anti-inflammatory medications, including NSAIDs (nonsteroidal anti-inflammatory drugs)
Analgesics (pain relievers)
Antibiotics (inhibit or kill microorganisms such as bacteria)
Antineoplastics (used to treat certain types of cancer or hypercalcemia – too much calcium in the blood)
Some migraine medications
Some anticonvulsants (medications to treat seizures or epilepsy)
Some gout medications

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Review Date: 03-07-2007

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