The aortic arch is the top portion of the aorta that develops between the fifth and seventh week of pregnancy. Aortic arch syndrome refers to a group of conditions associated with an abnormal structure of one or more of the arteries that branch out from the aortic arch. Symptoms include neurological changes, blood pressure changes, blood clots and reduced pulse. This syndrome can be congenital (from birth) or arise as a complication of coronary artery disease (CAD), blood clots or trauma (such as an accident).

Interrupted aortic arch is another associated condition of the aortic arch in which there is literally an interruption along the aorta. It may occur with ventricular septal defect, another form of congenital heart disease. Surgical repair is usually necessary.