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The risk of contracting a cold or flu (influenza) decreases with age. By the time children reach their teenage years, they average between two and four colds per year, which is similar to adults. Adolescents may have developed resistance to viral infections based on their exposure to specific colds or flu viruses through the years. However, teenagers engage in extensive social interaction with people in peer groups and others, so they remain at an increased risk of exposure to cold and flu viruses. 

Aspirin should not be used in children (including teenagers), especially when the child has a viral infection, due to the risk of the rare Reye syndrome.

Adolescents are also at an age when they may experiment with certain substances, such as alcohol and cigarettes, which can increase the risk of catching a cold or the flu. These substances may also make cold or flu symptoms more severe and last longer.