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Crohn's Disease

- Summary
- About Crohn's disease
- Potential complications
- Types and differences
- Risk factors and causes
- Signs and symptoms
- Diagnosis methods
- Treatment options
- Prevention methods
- Coping with Crohn's Disease
- Ongoing research
- Questions for your doctor

Reviewed By:
David Friedel, M.D., AGA

Types and differences of Crohn's disease

Crohn’s disease (CD) may be classified into various types, depending on the location of symptoms. CD most commonly affects the small intestine (made up of the duodenum, jejunum and ileum) and the large intestine (cecum, colon and rectum). The various types of CD include:

  • Ileocolitis. The most common form of CD, with symptoms occurring in both the small intestine’s ileum and the first part (cecum) of the large intestine. Symptoms include diarrhea, significant weight loss, and cramping or pain in the lower right or middle of the abdomen.

  • Ileitis. When inflammation occurs in the ileum (also referred to as the “terminal ileum”). The symptoms are similar to those of ileocolitis, although fistulae and abscesses may also develop.

  • Gastroduodenal Crohn’s disease. Affects the stomach and small intestine’s duodenum. Symptoms include loss of appetite, nausea, vomiting and weight loss. Vomiting may indicate an intestinal obstruction.

  • Jejunoileitis. Inflammation of the jejunum, the largest part of the small intestine. Symptoms include diarrhea, abdominal pain and cramping. Malnutrition may occur, due to malabsorption by the jejunum, where most absorption of nutrients occurs. Fistulae may also develop.
CD is distinguished from ulcerative colitis (UC) in a number of ways. CD can affect areas within the entire digestive tract whereas UC symptoms only appear in the large intestine. UC inflammation is always continuous whereas CD inflammation may appear in patches. In addition, UC does not cause deep-tissue irritation – its inflammation affects just the inner (mucosal) lining of the intestinal wall. Thus, UC is less likely to lead to intestinal obstructions or perforations that can require surgical treatment (as can happen with CD).

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Review Date: 12-06-2006
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