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Most cases of diaper rash can be identified without a visit to a physician. However, in some cases, patients may seek the care of a physician. This is especially true of many parents who encounter the condition in their child for the first time. During a visit to a physician, a complete physical examination will be performed and a thorough medical history compiled. In most cases, diaper rash can be diagnosed simply by making a visual examination of the skin. Microscopic examination of skin scrapings can help determine if the rash is caused by fungi or bacteria.

After diaper rash is identified, the best plan is to ensure that the skin remains as clean and dry as possible. Diaper rash may be treated with various over-the-counter medications, most of which contain zinc oxide.

In the past, experts recommended the use of talcum powder or cornstarch to protect a baby’s skin and absorb excess moisture. However, this is no longer advised because inhaled talcum powder can irritate a baby's lungs and cornstarch may promote the growth of yeast and bacteria.

When treated with home care, diaper rash usually subsides within two to three days. Diaper rash that persists may require prescription medications, such as antifungal creams (if the rash is caused by Candida infection), antibiotics (if the virus is caused by bacterial infection) or mild hydrocortisone creams. Rashes that persist for a period of weeks may necessitate a visit to a dermatologist.

A physician should be consulted before using over-the-counter treatments on a case of diaper rash. Prescription medications should only be used under the close supervision of a physician.