• Diuretics treat symptoms of heart failure by helping to flush fluids and minerals – primarily sodium – from the body.

  • ACE inhibitors minimize the effort the heart must make to pump blood and help to prevent further dilation or enlargement of the ventricle. This helps to relieve symptoms and, more importantly, directly increases the chance for long-term survival by reducing the stress on the heart muscle.

  • Angiotensin II receptor blockers work slightly differently than ACE inhibitors, but may also be used to increase the patient’s chance of survival by reducing the stress on the heart muscle.

  • Beta blockers have also been shown to increase the patient’s chance of survival, as well as to limit the number of hospitalizations for heart failure and improve symptoms. They can improve the ejection fraction by protecting the heart from high levels of hormones in the blood. These hormones may initially help the failing heart, but can then contribute to its progressive dysfunction.

  • Aldosterone inhibitors have recently been shown to prolong life when used along with standard medications. The landmark RALES study (Randomized Aldalactone Evaluation Study) found that, in patients with advanced heart failure already taking diuretics or ACE inhibitors, the addition of low-dose aldosterone inhibitor led to enhanced heart function and significant reduction in mortality.

  • Digoxin strengthens the heart muscle and helps slow the heart rhythm. This is used to treat certain rapid arrhythmias such as atrial fibrillation are present.

  • Vasodilators are sometimes recommended to lower a patient's blood pressure. This can make it easier for the heart to pump effectively by decreasing its workload.

  • Anticoagulant medications prevent the blood from clotting, and can help prevent embolisms in patients with dilated cardiomyopathy.

  • Ongoing studies are investigating whether some statins (a type of cholesterol reducing drug) exhibit a positive effect in dilated cardiomyopathy. Previous research with statins has already shown benefit on the coronary arteries of individuals with heart disease.