Psychotherapy is the primary treatment for dissociative identity disorder (DID). In most cases, patients are encouraged to remember any trauma they may have repressed and to work through it. Two types of therapy are particularly effective in treating conditions such as DID. Cognitive behavioral therapy helps patients to replace negative thoughts and behaviors with more positive alternatives. Creative art therapy teaches people to use outlets such as dance, art, drama, music and poetry to express thoughts and feelings and cope with trauma.

There are no medications specifically intended to treat DID. However, some medications, including antidepressants, anti-anxiety medications and tranquilizers may help with some specific symptoms such as anxiety and depression, but do not affect the disorder itself.