Disease-modifying antirheumatic drugs (DMARDs) each have different chemical properties. Accordingly, DMARDs may respond differently depending on the condition being treated, the drug being used, the dosage and characteristics of the patient.

In general, patients are encouraged to drink a lot of fluids to increase urine output. Prolonged exposure to sunlight should be avoided when DMARDs are prescribed, including the use of a highly protective sunscreen. In addition, because DMARDs may affect the immune system, proper oral hygiene will help prevent mouth infections from occurring.

Potentially serious side effects or reduced effectiveness of DMARDs may occur in patients with any of the following conditions:

• DMARD allergies
• Alcoholism
• Bone marrow or blood toxicities
• Pregnancy or breastfeeding
• Uncontrolled high blood pressure
• Dermatitis
• Kidney or liver damage, including hepatitis
• Uncontrolled diabetes
• Colitis
• Cancer