Dopamine blockers and depletors are medications that prevent the body from using or producing the neurotransmitter dopamine. Drugs that reduce dopamine’s effect in the body can be divided into two major categories: blockers and depletors. Dopamine blockers (also called dopamine receptor antagonists) prevent the body from using dopamine. Dopamine depletors decrease the amount of dopamine that is stored and released by neurons (nerve cells) in the brain and elsewhere in the body.

These drugs can be used to treat a number of health conditions that are related to the over-production or increased activity of dopamine. These conditions may include Huntington’s disease, Tourette syndrome and schizophrenia.

While drugs that block or deplete dopamine can have beneficial effects in treating some conditions, they can also cause side effects similar to symptoms of Parkinson’s disease. For example, dopamine blockers and depletors can cause slowness of movement and mobility problems. Symptoms of overdose can be similar to side effects, but are usually more severe.

Patients should not take some types of dopamine blockers and depletors if they have been diagnosed with certain conditions. In addition, various medications may interact poorly with dopamine blockers and depletors.

Certain dopamine blockers and depletors should not be taken by women who are pregnant or breastfeeding, or by children. However certain other dopamine blockers and depletors may be taken safely. In general, dopamine blockers and depletors may be safely used by older patients, although their dosage levels may need to be adjusted. Patients in these populations are urged to consult with their physician about the benefits and risks of using these medications.