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Dopamine Precursors

Also called: Dopamine Replacement, Dopamine Replacement Therapy

- Summary
- About dopamine precursors
- Conditions treated
- Conditions of concern
- Potential side effects
- Drug or other interactions
- Symptoms of overdose
- Pregnancy use issues
- Child use issues
- Elderly use issues
- Questions for your doctor

Reviewed By:
Andrew Biondo, D.O.

Drug or other interactions with precursors

Patients should consult their physician before taking any additional prescriptions, over-the-counter medications, nutritional supplements or herbal medications.

Certain medications may interfere with dopamine precursors such as levodopa (also known as L-Dopa). These include:

  • Alcohol

  • Antacids

  • Antidepressants

  • Antiseizure drugs

  • Antihypertensives

  • Dopamine blockers (e.g., antipsychotics, tranquilizers)

  • MAO inhibitors

  • Certain illegal drugs (e.g., cocaine)

  • Tranquilizers

  • Vitamin preparations with pyridoxine (vitamin B6) and other vitamins

In addition, a diet that is high in protein or vitamin B6 may prevent levodopa from being efficiently absorbed. Foods rich in vitamin B6 include beans, fish, liver, peas and whole-grain cereals. Protein can delay levodopa absorption. On the other hand, sugar may increase the speed of levodopa absorption. In general, taking levodopa on an empty stomach increases its therapeutic effect, but also increases certain side effects such as nausea. Patients are urged to discuss with their physician how to plan a proper diet while taking dopamine precursors.

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Review Date: 05-31-2007
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