What happens after the drug desensitization therapy depends on the drug allergy, the patient's condition and other factors. Some patients can go home right after the therapy but others will need to stay for some time to be monitored by the physician.

Some patients will continue to take the drug for maintenance after the initial desensitization therapy takes place. Maintenance doses may be achieved in five to 10 days. This method is often used for aspirin allergies. The physician will tell patients what is appropriate for their situation.

Long-term maintenance doses require an administration schedule specific to the patient and the drug. Maintenance doses will change to a daily, weekly, biweekly or monthly schedule depending on the situation.

Desensitization may be repeated in some cases of medicine allergies. When use of a medication is intermittent or interrupted, the desensitization process will have to be repeated from the beginning. For instance, patients desensitized to an antibiotic will stop taking the medication once the infection is resolved. If those patients have a similar infection in the future, they will need to complete desensitization therapy again in order to take the antibiotic. Their desensitization to the drug was lost when they stopped taking the medication.

Patients should ensure that they maintain the best state of health they can after therapy. Adequate rest, good nutrition and exercise are important. This will help boost the immune system and benefit their overall health. Patients should stay in contact with the physician and raise any issues when necessary.