• Heart murmurs, particularly when accompanied by regurgitation

  • A prior case of endocarditis

  • The presence of one or more artificial heart valves

  • Certain heart defects or heart diseases that are present since birth (e.g., patent ductus arteriosus, ventricular septal defect, coarctation of the aorta)

  • Any type of valvular heart disease (e.g., valvular stenosis, valvular regurgitation, mitral valve prolapse)

  • The presence of surgical shunts from the aorta to the pulmonary artery

  • Illegal intravenous (I.V.) drug use

  • A prior history of rheumatic fever

  • Excessive alcohol use

  • Infection with HIV, AIDS or other diseases that affect the immune system

  • Diabetic patients undergoing hemodialysis