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Ongoing research about endometrial cancer

A significant amount of research is being conducted in all areas of endometrial cancer. Scientists are studying molecular changes that can cause healthy endometrial cells to become cancerous. In addition, studies are examining the role of DNA in the risk of developing endometrial cancer. Inherited defects in certain genes may occur in families, increasing their risk for the disease. One normal gene, known as PTEN, is responsible for suppressing the growth of tumors in individuals. This gene often appears as abnormal in patients with endometrial cancer. Other DNA changes are being studied to help predict the aggressiveness of a cancer and to develop the best treatment methods for this type of disease.

Researchers are also studying tumor marker tests that may be used to help detect the presence of certain cancers. Recent studies indicate that the CA 125 blood test, a tumor marker test, may be useful in predicting the recurrence of endometrial cancer before tumors can be viewed on imaging tests. This test can be beneficial to physicians in planning treatment and monitoring patients for a recurrence of the disease.

Hormone replacement therapy (HRT) is also being studied by a research group known as the Women's Health Initiative (WHI). The WHI receives funding from the National Institutes of Health to study women's cancers. Among other studies, the WHI is investigating the association of HRT and women's reproductive cancers.

Researchers continue to study new chemotherapy drugs or combinations of drugs in patients with endometrial cancer. Chemotherapy with or without radiation is also be evaluated for its effectiveness.