Patients usually characterize fatigue as a feeling of lacking energy or feeling weak, tired, worn out, exhausted, weary or slow. Fatigue may be associated with an increased need for rest or the inability to regain energy after rest periods.

 Psychological symptoms associated with fatigue may include:

• Lack of motivation
• Lethargy
• Sadness
• Irritability
• Frustration
• Apathy

There are also physical responses to fatigue, which may include:

• Inability to sleep
• Oversleeping
• Drowsiness
• Feeling of heaviness in the arms and legs
• Muscle pain
• Headaches