Some fibrates (e.g., clofibrate) may result in stomach upset and should therefore be taken with food. Others should be taken before eating (e.g., gemfibrozil). Patients should carefully follow the directions for taking their medication provided by their physician and pharmacy. Those who miss a dose of this medication should take it as soon as possible, unless it is nearly time for the next dose. In that case, the missed dose should be skipped. Double doses of this medication should not be taken. Patients who are taking fibrates should receive regular check-ups to monitor their progress and cholesterol levels.

Fibrates may be less effective in people who are significantly overweight. Therefore, in addition to lifestyle changes recommended to reduce blood fat levels, patients may be placed on a weight loss program. In many cases, the lifestyle changes needed to manage blood fats will be similar to those in a weight loss program (e.g., diet, exercise, stress management).

Patients should not abruptly stop or change the dosage and timing of their medications without first consulting their physicians. It is also important that patients notify all physicians (including dentists) that they are taking fibrates before undergoing any surgical procedure.

Certain fibrates (e.g., fenofibrate) may increase an individual’s sensitivity to sunlight. Therefore, those taking these medications are encouraged to wear plenty of sunscreen (sun protection factor 15 or higher) and to take other precautions when spending time outdoors. Such measures include finding shade whenever possible, avoiding peak sunlight hours, staying covered with lightweight clothing and wearing a wide brimmed hat and sunglasses.

Most patients on medication to treat high cholesterol (hypercholesterolemia) will be taking it for the rest of their lives, provided no serious side effects occur. Patients should remember that medications may control high cholesterol, but they do not cure it. Even if all their symptoms are relieved, patients should continue to take their medication exactly as directed, eat a heart-healthy diet that is low in saturated fats and keep all scheduled follow-up appointments with their physician.