There is no special preparation for a fructosamine test. The blood sample can be taken at any time, without the fasting that some glucose tests require. Because vitamin C and some medications can interfere with the test, patients may be asked to stop taking these substances at some point before the test.

The test is performed in a physician’s office for laboratory analysis. Blood is usually drawn from a vein (venipuncture) from the inside of the elbow or the back of the hand. First the puncture site is sterilized with antiseptic and an elastic band is wrapped around the patient’s upper arm. As a result, the pressure restricts blood flow through the vein and causes the veins below the band to fill with blood.

A needle is then inserted into a vein. Occasionally more than one puncture is necessary to locate a vein. Some people may feel a moderate level of pain when the needle is inserted, but most feel only a prick or stinging sensation. Once the needle is inserted into a vein, a tube is attached to collect the blood as it begins to flow out. The elastic band is then removed.

After the necessary amount of blood is collected, the needle is withdrawn and a small cotton ball or pad is applied with light pressure over the puncture site. After several minutes, the cotton will be discarded or replaced, and a small bandage will be placed on the puncture wound. The entire process takes less than 10 minutes. The sample is sent to a laboratory for analysis, and results are returned in several days.

Despite the precautions taken to avoid bruising and soreness, it does sometimes occur. Typically, this is not a cause for concern. To minimize soreness, patients may immediately apply a warm compress to the puncture site and repeat the application every three hours until the discoloration or pain subsides.

Patients may resume taking vitamins and medication according to their physician’s orders.