Although scientists are currently working to develop a safe, effective vaccine for gonorrhea, no vaccine exists at this time. However, people can help prevent gonorrhea by practicing safe sex. This includes always using latex condoms during sex, minimizing the number of sexual partners, knowing the sexual history of sexual partners and testing for sexually transmitted diseases (STDs). The use of a latex dental dam during oral sex can minimize the risk of contracting gonorrhea in the throat. Abstinence from all sexual activity can completely prevent the disease.

People at high risk for STDs should be tested regularly for gonorrhea and have frank discussions with their physician about their sexual activity. STD testing is not a standard part of gynecological exams, so women should request an STD test if they are concerned about their exposure. Pregnant women should be tested for gonorrhea and treated if necessary. Babies born in hospitals may be treated with silver nitrate eye drops to prevent gonorrhea in their eyes.