A physician trying to diagnose an allergy related to intimacy will take a medical history and perform a physical exam. Allergy tests may be performed to determine the nature of an allergy. One method of confirming a semen allergy diagnosis is for a patient to abstain from sexual intercourse or use condoms during sexual intercourse. If no symptoms appear afterward, an allergy to semen is considered very likely.

Medications are also available to treat symptoms related to intimacy allergies. For example, corticosteroids may be used to treat skin reactions caused by intimate allergies. Patients with a history of severe reactions may be prescribed an allergy kit. In some cases, intimate allergies resolve without treatment.