Certain forms of mast cell stabilizers may not be advised for patients with some conditions. Patients with any of the following conditions should discuss the benefits and risks of mast cell stabilizer use with their physicians:

• Kidney disease. This condition may affect the concentration of medication in the body, increasing the effects of the medication. It is of particular concern for nasal sprays and oral treatments (pills and liquids).
  
  
• Liver disease. This condition may interfere with the concentration of medication in the body.
  
  
• Polyps (growths in the nose).  Obstructions of the nasal passageway may prevent mast cell stabilizer nasal sprays from working effectively.
  
  
• Heart disease or abnormal heartbeat. The propellants used in the aerosol form (inhalers) of mast cell stabilizers can worsen these conditions.
  
  
• High blood pressure. This condition can become exacerbated when using oral mast cell stabilizers (e.g., pills, liquids).
  
  
• Eye infections. Mast cell stabilizer eye drops can interfere with the treatment of eye infections.

In addition, some people may be allergic to mast cell stabilizers, though this is rare. Patients should not use a mast cell stabilizer if they are allergic to any of its ingredients.