There is generally a very low risk of overdose with this type of medication. Symptoms of mast cell stabilizer overdose can be similar to the medication’s side effects, but are usually more intense. An overdose is unlikely to require additional medical treatment and is usually treated by discontinuing or reducing the amount of medication used. People who experience intense side effects with this type of medication should immediately contact their physician.

Mast cell stabilizers have not been tested in pregnant women. However, testing in animals suggests that large amounts of some injected mast cell stabilizers (cromolyn) can cause pregnancy complications as well as a decrease in the weight of the animal fetus. Pregnant women should not use mast cell stabilizers unless specifically instructed to by a physician aware of the pregnancy.

Using cromolyn in an eyedrop or inhaled form is unlikely to cause any interference with pregnancy. Animal and human studies with the mast cell stabilizers nedocromil and lodoxamide have not shown an increased risk of birth defects.

It is not currently known if mast cell stabilizers pass into breast milk. No problems with nursing babies have thus far been reported. However, most types of medications pass into breast milk in very small amounts, and breastfeeding mothers should contact their physician before using a mast cell stabilizer.