Symptoms related to polypharmacy are often confused with signs of aging, particularly in older patients. Indications of problems in managing multiple medications may include:

• Fatigue, sleepiness or lack of alertness
• Constipation, diarrhea or incontinence
• Lack of appetite
• Weakness or incoordination
• Dizziness, fainting or falls
• Irregular heartbeat
• Allergic reaction
• Skin rashes
• Tremors
• Anxiety
• Depression or withdrawal
• Loss of interest in sex
• Confusion or decreased safety awareness
• Hallucinations (visual or auditory)