Mouth guards usually need minimal care. They should be washed with soap and warm water. However, it is important not to use hot water because this can cause the mouth guard to lose its shape. Likewise, mouth guards should not be left in the sun or in warm places such as a closed automobile. A toothbrush and toothpaste may be used to clean the mouth guard.

Mouth guards should be soaked in an antiseptic mouthwash before they are stored. They should be stored in a plastic container that is properly ventilated so the mouth guard will dry thoroughly. Patients should be careful not to bend the mouth guard while cleaning or storing it.

Over time, mouth guards may wear out, which reduces their ability to protect the mouth and teeth. In addition, a worn mouth guard may irritate the teeth and surrounding oral tissues. For these reasons, mouth guards should be replaced as soon as they develop holes or tears, or once they start to become loose.