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Patients with narcolepsy are encouraged to talk to employers or teachers about their condition and ways to accommodate their needs. The Americans with Disabilities Act prohibits discrimination against employees with medical conditions such as narcolepsy.

Patients are also encouraged to take caution to help ensure that they remain safe during certain activities. For example, patients should talk to their physician about what they can do to stay alert during long drives and should arrange to take naps or engage in forms of exercise at times when they feel especially drowsy.

In addition, patients can make several lifestyle changes that can help keep narcolepsy better contained. These include going to bed and waking up at the same time every day, taking short naps throughout the day and getting regular exercise, which can help patients stay more alert during the day and sleep better at night. Caffeine, nicotine and alcohol use should be avoided, because these substances can worsen symptoms. Heavy meals should also be avoided.