About 20 types of nonsteroidal anti-inflammatory drugs (NSAIDs) have been approved by the U.S. Food and Drug Administration (FDA). Each type affects the body differently, with individuals responding better to some types than others. Physicians often switch between different NSAIDs to find the drug that works best for a patient with the fewest side effects. The choice of one NSAID over another should be made after considering an individual’s risk factors for these potential side effects.

Rofecoxib, an NSAID belonging to the COX-2 inhibitor subclass, was removed from the market by the manufacturer after it was found to increase the risk of heart attack and stroke. Another, valdecoxib, was taken off the market because of cardiovascular and gastrointestinal risks. The use of valdecoxib was also found to increase the rate of rare serious skin reactions.

NSAIDs approved for sale in the United States include: