Any subsequent treatment of polydipsia is determined by the cause of the increased thirst. These possible sources can include type 1 diabetes, type 2 diabetes, dehydration, diabetes insipidus and others (see Potential causes).

Once the cause has been found, the course of treatment can begin. For example, the patient may be advised to take certain medications or discontinue other medications.

In most instances, polydipsia cannot be prevented as the occurrences are directly related to the cause and, in fact, may be early warning signs of disease. In the case of psychogenic polydipsia, psychological counseling may be advised.