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In addition to diabetes, hyperglycemia, hypoglycemia and diabetic ketoacidosis, common causes of polyphagia include:
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Increased exercise.
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Growth spurt.
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Anxiety, depression, bipolar disorder or eating disorders such as bulimia.
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Premenstrual syndrome (PMS).
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Pregnancy.
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Certain drugs, including corticosteroids (a class of anti-inflammatory immunosuppressives), antidepressants, some antidiabetic agents (e.g., sulfonylureas), antibiotics, anticonvulsants (sometimes used to treat diabetic neuropathy), antihistamines, cholesterol drugs, and cannabinoids such as marijuana.
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Hyperthyroidism, a condition characterized by a high level of thyroid hormone, caused by disorders including Graves’ disease.
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Hyperadrenalism (Cushing’s syndrome), a condition characterized by a high level of adrenal hormones.
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Damage to the hypothalamus (the part of the brain that controls hunger), which may be due to conditions such as head injury, tumor or encephalitis. Certain rare genetic diseases associated with polyphagia and obesity are thought to be due to inborn disorders of the hypothalamus, such as Prader-Willi syndrome.
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Intestinal parasites such as tapeworms.
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Kluver-Bucy syndrome, a rare disorder involving damage to the temporal lobes of the brain due to causes such as trauma, dementia or hypoglycemia.
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