The management and treatment of polyuria is entirely dependent on its cause. Once the underlying cause is determined, an appropriate treatment plan can be designed for the individual. A person with polyuria caused by medications or diet may be able to improve the condition with simple changes. However, individuals with diabetes may require changes in their diabetes management plan to achieve better control of their glucose (blood sugar) levels.

The prevention of frequent urination is also directly related to its cause. It may include taking medications, discontinuing medications, lifestyle modification and/or a medical procedure or surgery.

When diabetes is the cause, a patient can help prevent polyuria by keeping glucose levels within the target range. This can be achieved by adhering to a physician–recommended diabetes management plan, including a healthy diet, exercise, and insulin or antidiabetic agents. 

When episodes of high blood glucose (hyperglycemia) occur despite these efforts, a physician may recommend changes to the treatment plan. By controlling glucose, the patient can help prevent the symptoms of unstable diabetes, including the excessive need to urinate.