In general, no treatment is necessary for patients who are free of heart disease and are rarely bothered by symptoms of PVCs. For those who are bothered by their symptoms, the cause of the PVCs will be addressed if it can be identified. For example, patients whose PVCs are caused by excessive caffeine intake may be asked to limit or eliminate their use of caffeine. 

Patients whose PVCs appear to be associated with heart disease will be treated for those heart-related problems. For example, heart attack and heart failure patients may be prescribed beta blockers, while patients with high blood pressure may be prescribed antihypertensive medications to help prevent enlargement of the left ventricle.

If the cause of the PVCs cannot be identified, and symptoms are present, patients may be prescribed medications such as beta blockers. These drugs block certain actions of the sympathetic nervous system (e.g., the stress response) that could lead to a rapid heartbeat. Amiodarone, another anti-arrhythmic medication, may be used among people with symptomatic PVCs who cannot tolerate beta blockers. In rare cases, a procedure called catheter ablation may be necessary to eliminate the abnormal cells causing the PVCs. During this procedure, a specially designed catheter is used to destroy the parts of the heart that are causing the electrical disturbance.

Patients whose PVCs were successfully treated by eliminating the cause (e.g., caffeine) from their lifestyle are strongly encouraged to avoid that cause in the future. There are no known strategies for preventing PVCs in cases with no identifiable cause.