Patients should consult their physicians before using alcohol and/or taking any additional prescriptions, over-the-counter medications, nutritional supplements or herbal medications in conjunction with prokinetics.

Cisapride may interact poorly with many medicines. Some of these drugs include:

• Antispasmodics (medicines used to treat abdominal or stomach spasms or cramps)
  
  
• Certain antibiotics (e.g., erythromycin, clarithromycin)
  
  
• Antidepressants (medicines used to treat depression)
  
  
• Antidyskinetics (medicines used to treat Parkinson's disease or other conditions affecting muscle control)
  
  
• Antihistamines (drugs used to treat or reverse allergic reactions)
  
  
• Antipsychotics (medicines for mental illness, such as schizophrenia)
  
  
• Diuretics (water pills)
  
  
• Antifungals (drugs used to treat fungus and yeast infections)
  
  
• Antiemetics

Grapefruit and grapefruit juice may increase the effects of cisapride and should not be consumed while taking the medication.

Metoclopramide may interact poorly with the following drugs:

• Antispasmodics
• Antihypertensives (drugs used to treat high blood pressure)
• Antipsychotics
• Central nervous system depressants
• MAO inhibitors (a class of antidepressants)
• Cyclosporine (immunosuppressant that increases tear production)
• Digoxin (antiarrhythmic heart drug)

Patients who are taking metoclopramide should not drink alcohol, as it may increase feelings of depression.

Bethanecol may interact poorly with the following medications:

• Antispasmodics
• Antihypertensives
• Antiarrhythmics